S'identifier

Korea University of Science and Technology (UST)

2 ARTICLES PUBLISHED IN JoVE

Medicine

Measuring the Effect of Chemicals on the Growth and Reproduction of Caenorhabditis elegans

¹Systems Biotechnology Research Center, Korea Institute of Science and Technology

A basic protocol to evaluate the toxicity of chemicals in a model animal, Caenorhabditis elegans, is described. The method is convenient and useful for the development of pharmaceuticals as well as for the risk assessment of various environmental pollutants.

Medicine

Measuring the Effects of Bacteria and Chemicals on the Intestinal Permeability of Caenorhabditis elegans

Tram Anh Ngoc Le¹, Baskar Selvaraj^1,2, Jae Wook Lee^1,2, Kyungsu Kang^1,2

¹Gangneung Institute of Natural Products, Korea Institute of Science and Technology, ²Division of Bio-Medical Science & Technology, Korea University of Science and Technology (UST)

This protocol describes how to measure intestinal permeability of Caenorhabditis elegans. This method is helpful for basic biological research on intestinal health related to the interaction between intestinal bacteria and their host and for screening to identify probiotic and chemical agents to cure leaky gut syndrome and inflammatory bowel diseases.