A Large Animal Model for Pulmonary Hypertension and Right Ventricular Failure: Left Pulmonary Artery Ligation and Progressive Main Pulmonary Artery Banding in SheepRei Ukita 1, John W. Stokes 1, W. Kelly Wu 1, Jennifer Talackine 1, Nancy Cardwell 1, Yatrik Patel 1, Clayne Benson 5, Caitlin T. Demarest 1, Erika B. Rosenzweig 3, Keith Cook 2, Emily J. Tsai 4, Matthew Bacchetta 1,6
1Department of Thoracic Surgery, Vanderbilt University Medical Center, 2Department of Biomedical Engineering, Carnegie Mellon University, 3Department of Pediatrics, Columbia University Medical Center, Columbia University Irving Medical Center, 4Department of Medicine, Columbia University Medical Center, Columbia University Irving Medical Center, 5Department of Anesthesiology, Vanderbilt University Medical Center, 6Department of Biomedical Engineering, Vanderbilt University
This manuscript describes the surgical technique and experimental approach to develop severe right ventricular pressure overload to model their adaptive and maladaptive phenotypes.
