Quantification of GFP Expression in the Cerebellum
6:48
Rapid Quantification of the GFP-positive Fluorescent Area in the Cerebellum After Intravenous AAV Administration to the Rat
7:30
Conclusion
Transcription
The overall goal of this adeno-associated virus vector gene transfer is to genetically manipulate the rat's brain and spinal cord on an expansive wide scale basis. This method can help answer key questions in the gene transfer field. It is a very
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Methods for a wide-scale central nervous system gene delivery in the rat are covered. In this example, the purpose is to mimic a disease that affects the entire spinal cord. The widespread transduction can be used to deliver a therapeutic protein to the CNS from a one-time, peripheral administration.