September 24th, 2017
•The aim of the protocol is to present an optimized procedure for the establishment of an in vitro blood-brain barrier (BBB) model based on primary porcine brain endothelial cells (pBECs). The model shows high reproducibility, high tightness, and is suitable for studies of transport and intracellular trafficking in drug discovery.
Vidéos Connexes
MRI-guided Disruption of the Blood-brain Barrier using Transcranial Focused Ultrasound in a Rat Model
Rat Model of Blood-brain Barrier Disruption to Allow Targeted Neurovascular Therapeutics
Stretch in Brain Microvascular Endothelial Cells (cEND) as an In Vitro Traumatic Brain Injury Model of the Blood Brain Barrier
Setting-up an In Vitro Model of Rat Blood-brain Barrier (BBB): A Focus on BBB Impermeability and Receptor-mediated Transport
Excitotoxic Stimulation of Brain Microslices as an In vitro Model of Stroke
Oxygen-Glucose Deprivation and Reoxygenation as an In Vitro Ischemia-Reperfusion Injury Model for Studying Blood-Brain Barrier Dysfunction
An Improved Method for Rapid Intubation of the Trachea in Mice
An Anesthesia, Surgery, and Harvest Method for the Evaluation of Transpedicular Screws Using an In Vivo Porcine Lumbar Spine Model
In Vitro Assays to Assess Blood-brain Barrier Mesh-like Vessel Formation and Disruption
Establishment and Evaluation of a Porcine Vein Graft Disease Model