David DeShazer

Bacteriology Division

United States Army Medical Research Institute of Infectious Diseases

BIOGRAPHY

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PUBLICATIONS

Nonviable Burkholderia mallei induces a mixed Th1- and Th2-like cytokine response in BALB/c mice.

Infection and immunity May, 2002 | Pubmed ID: 11953366

Burkholderia thailandensis E125 harbors a temperate bacteriophage specific for Burkholderia mallei.

Journal of bacteriology Jul, 2002 | Pubmed ID: 12081973

Type III secretion: a virulence factor delivery system essential for the pathogenicity of Burkholderia mallei.

Infection and immunity Feb, 2004 | Pubmed ID: 14742564

Genomic diversity of Burkholderia pseudomallei clinical isolates: subtractive hybridization reveals a Burkholderia mallei-specific prophage in B. pseudomallei 1026b.

Journal of bacteriology Jun, 2004 | Pubmed ID: 15175308

Role of quorum sensing in the pathogenicity of Burkholderia pseudomallei.

Journal of medical microbiology Nov, 2004 | Pubmed ID: 15496380

Quorum sensing: a transcriptional regulatory system involved in the pathogenicity of Burkholderia mallei.

Infection and immunity Nov, 2004 | Pubmed ID: 15501791

Aerogenic vaccination with a Burkholderia mallei auxotroph protects against aerosol-initiated glanders in mice.

Vaccine Mar, 2005 | Pubmed ID: 15734072

Development of a polymerase chain reaction assay for the specific identification of Burkholderia mallei and differentiation from Burkholderia pseudomallei and other closely related Burkholderiaceae.

Diagnostic microbiology and infectious disease May, 2006 | Pubmed ID: 16546342

Polysaccharide microarray technology for the detection of Burkholderia pseudomallei and Burkholderia mallei antibodies.

Diagnostic microbiology and infectious disease Nov, 2006 | Pubmed ID: 16765554

Genome sequence alterations detected upon passage of Burkholderia mallei ATCC 23344 in culture and in mammalian hosts.

BMC genomics Sep, 2006 | Pubmed ID: 16953889

Virulence of clinical and environmental isolates of Burkholderia oklahomensis and Burkholderia thailandensis in hamsters and mice.

FEMS microbiology letters Dec, 2007 | Pubmed ID: 17986086

Comparative genomics and an insect model rapidly identify novel virulence genes of Burkholderia mallei.

Journal of bacteriology Apr, 2008 | Pubmed ID: 18223084

Burkholderia mallei cluster 1 type VI secretion mutants exhibit growth and actin polymerization defects in RAW 264.7 murine macrophages.

Infection and immunity Jan, 2010 | Pubmed ID: 19884331

Burkholderia thailandensis oacA mutants facilitate the expression of Burkholderia mallei-like O polysaccharides.

Infection and immunity Feb, 2011 | Pubmed ID: 21115721

The cluster 1 type VI secretion system is a major virulence determinant in Burkholderia pseudomallei.

Infection and immunity Apr, 2011 | Pubmed ID: 21300775

Humoral immune responses in a human case of glanders.

Clinical and vaccine immunology : CVI May, 2012 | Pubmed ID: 22398248

The Madagascar hissing cockroach as a novel surrogate host for Burkholderia pseudomallei, B. mallei and B. thailandensis.

BMC microbiology Jun, 2012 | Pubmed ID: 22892068

Characterization of the Burkholderia thailandensis SOS response by using whole-transcriptome shotgun sequencing.

Applied and environmental microbiology Oct, 2013 | Pubmed ID: 23872555

A high-content imaging assay for the quantification of the Burkholderia pseudomallei induced multinucleated giant cell (MNGC) phenotype in murine macrophages.

BMC microbiology , 2014 | Pubmed ID: 24750902

Proteomic analysis of the Burkholderia pseudomallei type II secretome reveals hydrolytic enzymes, novel proteins, and the deubiquitinase TssM.

Infection and immunity Aug, 2014 | Pubmed ID: 24866793

The chemical arsenal of Burkholderia pseudomallei is essential for pathogenicity.

Journal of the American Chemical Society Jul, 2014 | Pubmed ID: 24884988

Melioidosis: molecular aspects of pathogenesis.

Expert review of anti-infective therapy Dec, 2014 | Pubmed ID: 25312349

pH Alkalinization by Chloroquine Suppresses Pathogenic Burkholderia Type 6 Secretion System 1 and Multinucleated Giant Cells.

Infection and immunity Jan, 2017 | Pubmed ID: 27799332

Development of Subunit Vaccines that Provide High Level Protection and Sterilizing Immunity Against Acute Inhalational Melioidosis.

Infection and immunity Nov, 2017 | Pubmed ID: 29109172

INSTITUTIONS

United States Army Medical Research Institute of Infectious Diseases

JOVE ARTICLES

The Madagascar Hissing Cockroach as an Alternative Non-mammalian Animal Model to Investigate Virulence, Pathogenesis, and Drug Efficacy

Jennifer Chua¹,

Nathan A. Fisher²,

Shane D. Falcinelli¹,

David DeShazer¹,

Arthur M. Friedlander³

¹Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases,

², Southern Research,

³Headquarters Division, United States Army Medical Research Institute of Infectious Diseases

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