United States Army Medical Research Institute of Infectious Diseases

2 ARTICLES PUBLISHED IN JoVE

Immunology and Infection

The Madagascar Hissing Cockroach as an Alternative Non-mammalian Animal Model to Investigate Virulence, Pathogenesis, and Drug Efficacy

Jennifer Chua¹, Nathan A. Fisher², Shane D. Falcinelli¹, David DeShazer¹, Arthur M. Friedlander³

¹Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases, ²Southern Research, ³Headquarters Division, United States Army Medical Research Institute of Infectious Diseases

We present a protocol to utilize the Madagascar hissing cockroach as an alternative non-mammalian animal model to conduct bacterial virulence, pathogenesis, drug toxicity, drug efficacy, and innate immune response studies.

Immunology and Infection

Opsono-Adherence Assay to Evaluate Functional Antibodies in Vaccine Development Against Bacillus anthracis and Other Encapsulated Pathogens

Jennifer Chua^*1, Donald J. Chabot^*1, Tammy Putmon-Taylor^1,3, Arthur M. Friedlander²

¹Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases, ²Headquarters Division, United States Army Medical Research Institute of Infectious Diseases, ³Bioqual

The opsono-adherence assay is an alternative method to the opsono-phagocytic killing assay to evaluate the opsonic functions of antibodies in vaccine development.