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Arcturus Therapeutics

1 ARTICLES PUBLISHED IN JoVE

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Chemistry

A Workflow for Lipid Nanoparticle (LNP) Formulation Optimization using Designed Mixture-Process Experiments and Self-Validated Ensemble Models (SVEM)
Andrew T. Karl 1, Sean Essex 2, James Wisnowski 1, Heath Rushing 1
1Adsurgo, LLC, 2Arcturus Therapeutics

This protocol provides an approach to formulation optimization over mixture, continuous, and categorical study factors that minimizes subjective choices in the experimental design construction. For the analysis phase, an effective and easy-to-use modeling fitting procedure is employed.

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