An All-Human Hepatic Culture System for Drug Development ApplicationsJustin J. Odanga 1, Elena Gianulis 2, Lindsey Whaley 3, Edward L. LeCluyse 4, Sharon Presnell 1, Jessica R. Weaver 1
1Institute of Regenerative Medicine, LifeNet Health, 2Biologics Division, LifeNet Health, 3LifeSciences Division, LifeNet Health, 4Research and Development, LifeSciences, LifeNet Health
Recent technical advances enabled the scaled production of an in vitro platform for drug metabolism and toxicity applications. An all-human 2D+ hepatic system (TV2D+) provides physiologically relevant results using traditional two-dimensional culture methods. This protocol will support end-users in the setup, maintenance, and application of the system.
