Federal University of Sao Carlos

2 ARTICLES PUBLISHED IN JoVE

Neuroscience

An Experiment Using Functional Near-Infrared Spectroscopy and Robot-Assisted Multi-Joint Pointing Movements of the Lower Limb

João Ricardo Sato¹, Anna Carolyna Gianlorenço², Elayne Borges Fernandes², Thalita Frigo da Rocha², Antonio Massato Makiyama^*3, Laura Dipietro^*4

¹Center of Mathematics, Computing and Cognition, Universidade Federal do ABC, ²Department of the Physical Therapy, Federal University of Sao Carlos, ³Vivax Ltda, ⁴Highland Instruments

It is estimated that 1 in 6 individuals worldwide will have a stroke in their lifetime, causing long-term disability, whose rehabilitation mechanisms are still poorly understood. This study proposes a protocol to evaluate brain activation by functional near-infrared spectroscopy (fNIRS) during a lower limb robotic therapy session.

Neuroscience

Understanding the Effects of Non-Invasive Transauricular Vagus Nerve Stimulation on EEG and HRV

Anna Carolyna Gianlorenco^1,2, Kevin Pacheco-Barrios^1,3, Lucas Camargo¹, Elly Pichardo¹, Hyuk Choi^4,5, Jae-Jun Song^5,6, Felipe Fregni¹

¹Neuromodulation Center and Center for Clinical Research Learning, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Harvard Medical School, ²Physical Therapy Department, Federal University of Sao Carlos, ³Vicerrectorado de Investigación, Universidad de Investigación para la Generación y Síntesis de Evidencia en Salud, Universidad San Ignacio de Loyola, ⁴Department of Medical Sciences, Graduate School of Medicine, Korea University, ⁵Neurive Co., Ltd., ⁶Department of Otorhinolaryngology-Head and Neck Surgery, Korea University Medical Center

This protocol provides information on how to apply transcutaneous auricular vagus nerve stimulation (taVNS) in a clinical trial, including potential biomarkers such as EEG metrics and heart rate variability (HRV) to measure the effect of this treatment on the autonomic nervous system.