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Homi Bhabha National Institutes

1 ARTICLES PUBLISHED IN JoVE

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Biology

Fission Yeast as a Platform for Antibacterial Drug Screens Targeting Bacterial Cytoskeleton Proteins
Sakshi Mahesh Poddar 1,2, Srijita Roy 1,2, Ajay Kumar Sharma 1,2, Ramanujam Srinivasan 1,2
1School of Biological Sciences, National Institute of Science Education and Research, 2Homi Bhabha National Institutes

Fission yeast is used here as a heterologous host to express bacterial cytoskeletal proteins such as FtsZ and MreB as translational fusion proteins with GFP to visualize their polymerization. Also, compounds that affect polymerization are identified by imaging using a fluorescence microscope.

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