Photobiomodulation Under Electroencephalographic Controls of Sleep for Stimulation of Lymphatic Removal of Toxins from Mouse BrainInna Blokina 1, Egor Iluykov 2, Dmitry Myagkov 2, Dmitry Tuktarov 2, Sergey Popov 2, Timofey Inozemzev 2, Ivan Fedosov 2, Alexander Shirokov 1,3, Andrey Terskov 1, Alexander Dmitrenko 1, Arina Evsyukova 1, Daria Zlatogorskaya 1, Viktoria Adushkina 1, Matvey Tuzhilkin 1, Maria Manzhaeva 1, Valeria Krupnova 1, Alexander Dubrovsky 2, Inna Elizarova 1, Maria Tzoy 2, Oxana Semyachkina-Glushkovskaya 1
1Department of Biology, Saratov State University, 2Institute of Physics, Department of Optics and Biophotonics, Saratov State University, 3Institute of Biochemistry and Physiology of Plants and Microorganisms, Saratov Scientific Centre of the Russian Academy of Sciences
This study presents an original and portable tPBM technology under electroencephalographic (EEG) control of deep or non-rapid eye movement (NREM) sleep in non-anesthetized male C57BL/6 mice of different ages to stimulate lymphatic clearance of Aβ from the brain into the peripheral lymphatic system (the deep cervical lymph nodes, dcLNs).
