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Transcode Therapeutics Inc.

2 ARTICLES PUBLISHED IN JoVE

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Cancer Research

Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases
Alan Halim 1, Sujan Kumar Mondal 1,2, Nasreen Al-Qadi 1, Elizabeth Kenyon 1,2, Keith MacRenaris 3,5, Thomas V. O’Halloran 4,5, Zdravka Medarova 6, Anna Moore 1,2
1Precision Health Program, Michigan State University, 2Department of Radiology, College of Human Medicine, Michigan State University, 3Department of Microbiology, Genetics, & Immunology, College of Natural Science, Michigan State University, 4Department of Chemistry, College of Natural Science, Michigan State University, 5Elemental Health Institute, Michigan State University, 6Transcode Therapeutics Inc.

Here, we describe the protocol for in vivo delivery of magnetic iron oxide nanoparticles carrying RNA oligomers to metastatic breast cancer in animal models, providing a clinically viable approach for the therapeutic silencing of oncogenic nucleic acids.

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Nanoparticle Delivery of an Oligonucleotide Payload in a Glioblastoma Multiforme Animal Model

Nanoparticle Delivery of an Oligonucleotide Payload in a Glioblastoma Multiforme Animal Model
Bryan D. Kim 1,2, Sujan K. Mondal 1,3, Elizabeth Kenyon 1,3, Ming Chen 1,3, Christiane L. Mallett 3,4, Ana C. deCarvalho 5, Zdravka Medarova 6, Anna Moore 1,3
1Precision Health Program, Michigan State University, 2Department of Biomedical Engineering, College of Engineering, Michigan State University, 3Department of Radiology, College of Human Medicine, Michigan State University, 4Institute for Quantitative Health Science and Engineering, Michigan State University, 5Henry Ford Health, 6Transcode Therapeutics Inc.

The blood-brain barrier is a significant hurdle in the delivery of therapies for glioblastoma, a disease for which there is no cure. Here, we report an in vivo image-guided iron oxide therapeutic nano platform that can bypass this physiological barrier by virtue of size and accumulate in the tumor.

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