University of Bradford

2 ARTICLES PUBLISHED IN JoVE

Biology

Laser Capture Microdissection on Surgical Tissues to Identify Aberrant Gene Expression in Impaired Wound Healing in Type 2 Diabetes

Rachael Williams^*1, Irene Castellano-Pelicena^*1,2, Aaiad H.A Al-Rikabi^1,3, Stephen K. Sikkink¹, Richard Baker¹, Kirsten Riches-Suman¹, M Julie Thornton¹

¹Centre for Skin Sciences, University of Bradford, ²The Charles Institute of Dermatology, School of Medicine, University College Dublin, ³University of Baghdad

This technique provides a guide to inflicting ex vivo wounds, performing laser capture microdissection and quantifying changes in gene expression related to poor wound healing processes in diabetes using clinically relevant human tissue.

Medicine

An Experimental Approach to Induce Trips in Lower-Limb Amputees

André Luiz Felix Rodacki¹, John Gerard Buckley², Ana Carolina Passos de Oliveira³, Rauce Marçal da Silva³, Vitor Bertoli Nascimento³

¹Department of Physical Education, Federal University of Paraná, ²Department of Biomedical and Electronics Engineering, University of Bradford, ³Department of Occupational Therapy, Federal University of Paraná

An experimental approach was developed to induce trips in lower-limb amputees. The goal was to create unexpected trips and induce meaningful tripping/recovery responses. The kinematic data from one transtibial amputee confirmed that such an approach effectively elicits reactive trip recovery responses.