Radiosynthesis of 1-(2-[18F]Fluoroethyl)-L-Tryptophan using a One-pot, Two-step ProtocolXuyi Yue 1,2, Rahul M. Nikam 1,2, Heidi H. Kecskemethy 1,2, Vinay V. R. Kandula 2, Stephen J. Falchek 3, Lauren W. Averill 1,2, Sigrid A. Langhans 1,4
1Diagnostic & Research PET/MRI Center, Nemours/Alfred I. duPont Hospital for Children, 2Department of Radiology, Nemours/Alfred I. duPont Hospital for Children, 3Department of Neurology, Nemours/Alfred I. duPont Hospital for Children, 4Department of Biomedical Research, Nemours/Alfred I. duPont Hospital for Children
Here, we describe the radiosynthesis of 1-(2-[18F]Fluoroethyl)-L-tryptophan, a positron emission tomography imaging agent for studying tryptophan metabolism, using a one-pot, two-step strategy in a radiochemistry synthesis system with good radiochemical yields, high enantiomeric excess, and high reliability.
