Evaluating Salidroside as a Therapeutic Agent for Vascular Calcification Using Network Pharmacology and Experimental Rat ModelsHan-Ying Xu *1, Xiao-Lei Tang *2, Peng-Fei Li 3, Dong-Mei Zhang 4, Guang Ta 5, Jing Lu 2, Jian Wang 1
1Department of Encephalopathy, The Affiliated Hospital of Changchun University of Chinese Medicine, 2Research Center of Traditional Chinese Medicine, The Affiliated Hospital to Changchun University of Chinese Medicine, 3Department of Nephrology, The Affiliated Hospital to Changchun University of Chinese Medicine, 4Scientific Research Office, The Affiliated Hospital to Changchun University of Chinese Medicine, 5Rehabilitation Department, The Affiliated hospital to Changchun University of Chinese Medicine
This study establishes a rat model of vascular calcification induced by a high-fat diet (HFD) combined with vitamin D3 (VD3). The model was used to evaluate the therapeutic efficacy of salidroside in preventing and treating vascular calcification, providing insights into its potential mechanisms of action through network pharmacology and in vivo experiments.
