Tumor Hypoxia Assessment: In Vivo 3D Oxygen Imaging Through Electron Paramagnetic Resonance Gabriela Dziurman 1,2, Aleksandra Bienia 1,2, Aleksandra Murzyn 1,2, Bartosz Płóciennik 1,2, Julia Kozik 1, Grzegorz Szewczyk 1, Małgorzata Szczygieł 1, Martyna Krzykawska-Serda 1, Boris Epel 3,4,5, Howard J. Halpern 3,4, Martyna Elas 1
1Faculty of Biochemistry, Biophysics and Biotechnology, Department of Biophysics and Cancer Biology, Jagiellonian University, 2Doctoral School of Exact and Natural Sciences Faculty of Biochemistry, Biophysics and Biotechnology, Department of Biophysics and Cancer Biology, Jagiellonian University, 3Department of Radiation and Cellular Oncology, The University of Chicago, 4Center for EPR Imaging In Vivo Physiology, The University of Chicago, 5O2M Technologies
Quantitative 3D oxygen maps of murine tumors were imaged noninvasively using Pulse Electron Paramagnetic Resonance. Ultrasound B-mode and Power Doppler were used for anatomy and vascular structure. Images from both modalities were superimposed enabling multi-parametric tumor analysis.
