A Modified Mouse Model of Intracranial Aneurysm Based on Hemodynamic Change and HypertensionYongquan Han *1,2, Hao Qin *3, Junshuan Cui 4, Xi Zeng 4, Bing Zhao 1
1Department of Neurosurgery, Renji Hospital, Shanghai Jiaotong University School of Medicine, 2Department of Neurosurgery, The Second Affiliated Hospital, Guangzhou Medical University, 3Department of Neurosurgery, Zaozhuang Municipal Hospital, 4Department of Neurosurgery, the Affiliated Hospital of Guizhou Medical University
Intracranial aneurysm (IA) was constructed in mice using the risk factors of hypertension and hemodynamic changes. Hemodynamic changes were induced by ligating branches of the carotid artery, while hypertension was achieved by ligating the posterior branches of the renal artery. IA formation was detected through magnetic resonance angiography, stereomicroscopy, and pathological analysis.
