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Rowan University

6 ARTICLES PUBLISHED IN JoVE

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Bioengineering

Designing Silk-silk Protein Alloy Materials for Biomedical Applications
Xiao Hu 1,2,3, Solomon Duki 1, Joseph Forys 1, Jeffrey Hettinger 1,2, Justin Buchicchio 1, Tabbetha Dobbins 1,2, Catherine Yang 2,4
1Department of Physics and Astronomy, Rowan University, 2Department of Biomedical and Translational Sciences, Rowan University, 3Department of Biomedical Sciences, Cooper Medical School of Rowan University, 4Department of Chemistry and Biochemistry, Rowan University

Blending is an efficient approach to generate biomaterials with a broad range of properties and combined features. By predicting the molecular interactions between different natural silk proteins, new silk-silk protein alloy platforms with tunable mechanical resiliency, electrical response, optical transparency, chemical processability, biodegradability, or thermal stability can be designed.

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Neuroscience

Flat Mount Imaging of Mouse Skin and Its Application to the Analysis of Hair Follicle Patterning and Sensory Axon Morphology
Hao Chang 1, Yanshu Wang 1, Hao Wu 1, Jeremy Nathans 1,2,3
1Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, 2Department of Neuroscience, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, 3Department of Ophthalmology, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine

Mammalian skin contains a diverse array of structures - such as hair follicles and nerve endings - that exhibit distinctive patterns of spatial organization. Analyzing skin as a flat mount takes advantage of the 2-dimensional geometry of this tissue to produce full-thickness high-resolution images of skin structures.

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Bioengineering

Synthesis of Thermogelling Poly(N-isopropylacrylamide)-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering
Thomas R. Christiani 1, Katelynn Toomer 2, Joseph Sheehan 2, Angelika Nitzl 2, Amanda Branda 2, Elizabeth England 2, Pamela Graney 3, Cristina Iftode 2, Andrea J. Vernengo 1
1Department of Chemical Engineering, Rowan University, 2Department of Biological Sciences, Rowan University, 3Department of Biomedical Engineering, Drexel University

An injectable tissue engineering scaffold composed of poly(N-isopropylacrylamide)-graft-chondroitin sulfate (PNIPAAm-g-CS)-containing alginate microparticles was prepared. The adhesive strength, swelling properties and in vitro biocompatibility are analyzed in this study. The characterization techniques developed here may be applicable to other thermogelling systems.

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Medicine

An Acute Retinal Model for Evaluating Blood Retinal Barrier Breach and Potential Drugs for Treatment
Hao Wu 1, Ana R. Rodriguez 2, Bernd W. Spur 2, Venkat Venkataraman 1,2
1Graduate School of Biomedical Sciences, Rowan University, 2Department of Cell Biology, Rowan University School of Osteopathic Medicine

A low-cost, easy-to-use and powerful system is established to evaluate potential treatments that could ameliorate blood retinal barrier breach induced by histamine. Blood vessel leakage, Müller cell activation and the continuity of neuronal processes are utilized to assess the damage response and its reversal with a potential drug, lipoxin A4.

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Genetics

Measuring mRNA Levels Over Time During the Yeast S. cerevisiae Hypoxic Response
Stephen D. Willis 1, A. K. M. Nawshad Hossian 2, Nathan Evans 2, Mark J. Hickman 2
1Department of Molecular Biology, Rowan School of Osteopathic Medicine, 2Department of Biological Sciences, Rowan University

Here, we present a protocol using RNA-seq to monitor mRNA levels over time during the hypoxic response of S. cerevisiae cells. This method can be adapted to analyze gene expression during any cellular response.

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Neuroscience

The Sol Braiding Method for Handling Thick Hair During Transcranial Magnetic Stimulation: An Address for Potential Bias in Brain Stimulation
Qiana Archer 1, Janet Brenya 1, Katherine Chavaria 2, Anjel Friest 3, Nathira Ahmad 4, Samantha Zorns 1, Sahana Vaidya 1, Taylor Shelanskey 1, Sarah Sierra 1, Sydney Ash 1, Briana Balugus 5, Alexa Alvarez 6, Mathew Pardillo 1, Roy Hamilton 7, Julian Paul Keenan 1
1Cognitive Neuroimaging Laboratory, Montclair State University, 2School of Osteopathic Medicine, Rowan University, 3Department of Biology, Rutgers University, 4Department of Health Informatics, Rutgers University, 5Department of Physician Assistant, Seton Hall University, 6School of Nursing, Felician College, 7Laboratory for Cognition and Neural Stimulation, University of Pennsylvania

Hair type commonly seen in historically underrepresented minorities appears to interfere with transcranial magnetic stimulation (TMS). Here we describe a hair braiding method (The Sol Braiding Technique) that improves TMS.

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