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Maastricht University Medical Center

3 ARTICLES PUBLISHED IN JoVE

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Immunology and Infection

One-day Workflow Scheme for Bacterial Pathogen Detection and Antimicrobial Resistance Testing from Blood Cultures
Wendy L.J. Hansen 1, Judith Beuving 1, Annelies Verbon 2, Petra. F.G. Wolffs 1
1Department of Medical Microbiology, Maastricht University Medical Center, 2Department of Internal Medicine, Erasmus Medical Center

The design of a straightforward one-day workflow scheme for bacterial pathogen diagnostics enables the rapid recognition of bloodstream infections. The inclusion of eight clinically relevant bacterial targets and their antibiotic resistance profiles offers the clinician an initial insight on the same day, which can lead to more adequate therapy.

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Developmental Biology

Gut Isolation from Zebrafish Larvae for Single-cell RNA Sequencing
Naomi J. M. Kakiailatu 1, Laura E. Kuil 1,2, Eric Bindels 3, Joke T. M. Zink 3, Michael Vermeulen 3, Veerle Melotte 4, Maria M. Alves 1
1Department of Clinical Genetics, Erasmus University Medical Center - Sophia Children's Hospital, 2Division of Psychosocial Research and Epidemiology, the Netherlands Cancer Institute, 3Department of Hematology, Erasmus Medical Center, 4Department of Pathology, GROW-School for Oncology and Developmental Biology, Maastricht University Medical Center

Here, we describe a method for gut isolation from zebrafish larvae at 5 days post fertilization, for single-cell RNA sequencing analysis.

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Cancer Research

Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-labelled Nano Molecules
Betül Altunay 1, Matthias Bauwens 1,2,3, Laura Schäfer 1, Amelie Heesch 1, Agnieszka Morgenroth 1, Felix M. Mottaghy 1,2,4, Alexandru Florea 1,2,4
1Department of Nuclear Medicine, University Hospital RWTH Aachen, 2Department of Radiology and Nuclear Medicine, Maastricht University Medical Center, 3School of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University, 4School for Cardiovascular Diseases (CARIM), Maastricht University

This paper describes the radiosynthesis, formulation, quality control of a new radiolabeled probe (i.e., 68Ga-labeled nanobody NM-02), and its use for small animal PET/CT imaging in a xenograft model.

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