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Hamburg University of Technology

4 ARTICLES PUBLISHED IN JoVE

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Neuroscience

Experimental Strategies to Bridge Large Tissue Gaps in the Injured Spinal Cord after Acute and Chronic Lesion
Nicole Brazda *1, Veronica Estrada *1, Christian Voss 2,3, Klaus Seide 3, Hoc Khiem Trieu 2, Hans Werner Müller 1
1Molecular Neurobiology Laboratory, Department of Neurology, Heinrich-Heine-University Medical Center, 2Institute of Microsystems Technology, Hamburg University of Technology, 3Biomechanical Laboratory, BG Trauma Center Hamburg

Severe spinal cord injuries often result in tissue defects. Two possibilities are described to successfully bridge such gaps to promote tissue adaptation, regenerative responses and functional improvement in rats via implantation of a mechanical microconnector system after acute injury and five weeks after complete spinal cord transection.

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Chemistry

Preparation of Biopolymer Aerogels Using Green Solvents
Raman Subrahmanyam 1, Pavel Gurikov 1, Imke Meissner 1, Irina Smirnova 1
1Institute of Thermal Separation Processes, Hamburg University of Technology

A new way for the production of biopolymer-based aerogels by carbon dioxide (CO2) induced gelation is shown. The technique utilizes pressurized carbon dioxide (5 MPa) for the production of biopolymer hydrogels and supercritical CO2 (12 MPa) to convert gels into aerogels. The only solvents needed besides CO2 are water and ethanol.

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Bioengineering

A Method for Determination and Simulation of Permeability and Diffusion in a 3D Tissue Model in a Membrane Insert System for Multi-well Plates
Hao-Hsiang Hsu 1, John-Kevin Kracht 1, Laura Elisabeth Harder 1, Kerstin Rudnik 1, Gerd Lindner 2, Katharina Schimek 2, Uwe Marx 3, Ralf Pörtner 1
1Institute of Bioprocess and Biosystems Engineering, Hamburg University of Technology, 2Institute of Biotechnology, Department Medical Biotechnology, Technische Universität Berlin, 3TissUse GmbH

A method for determination of permeability in a membrane insert system for multi-well plates and in silico parameter optimization for the calculation of diffusion coefficients using simulation are presented.

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Engineering

Manufacturing, Control, and Performance Evaluation of a Gecko-Inspired Soft Robot
Lars Schiller 1, Arthur Seibel 2, Josef Schlattmann 1
1Workgroup on System Technologies and Engineering Design Methodology, Hamburg University of Technology, 2Fraunhofer Research Institution for Additive Manufacturing Technologies IAPT

This protocol provides a detailed list of steps to be performed for the manufacturing, control and evaluation of the climbing performance of a gecko-inspired soft robot.

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