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Max Planck Institute for Biological Cybernetics

7 ARTICLES PUBLISHED IN JoVE

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Neuroscience

MPI CyberMotion Simulator: Implementation of a Novel Motion Simulator to Investigate Multisensory Path Integration in Three Dimensions
Michael Barnett-Cowan 1, Tobias Meilinger 1, Manuel Vidal 2, Harald Teufel 1, Heinrich H. Bülthoff 1,3
1Department of Human Perception, Cognition and Action, Max Planck Institute for Biological Cybernetics, 2Laboratoire de Physiologie de la Perception et de l'Action, Collège de France - CNRS, 3Department of Brain and Cognitive Engineering, Korea University

An efficient way to gain insight into how humans navigate themselves in three dimensions is described. The method takes advantage of a motion simulator capable of moving observers in ways unattainable by traditional simulators. Results confirm that movement in the horizontal plane is underestimated, while vertical movement is overestimated.

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Behavior

Topographical Estimation of Visual Population Receptive Fields by fMRI
Sangkyun Lee 1, Amalia Papanikolaou 2, Georgios A. Keliris 2,3, Stelios M. Smirnakis 1
1Department of Neuroscience and Neurology, Baylor College of Medicine, 2Max Planck Institute for Biological Cybernetics, 3Bernstein Center for Computational Neuroscience

It is important to obtain unbiased estimates of visual population receptive fields (pRFs) by functional magnetic resonance imaging. We use mild regularization constraints to estimate pRF topography without a-priori assumptions about pRF shape, allowing us to choose specific pRF models post-hoc. This is particularly advantageous in subjects with visual-pathway lesions.

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Chemistry

Preparation and In Vitro Characterization of Dendrimer-based Contrast Agents for Magnetic Resonance Imaging
Serhat Gündüz 1, Tanja Savić 1, Đorđe Toljić 1, Goran Angelovski 1
1MR Neuroimaging Agents, Max Planck Institute for Biological Cybernetics

This protocol describes the preparation and characterization of a dendrimeric magnetic resonance imaging (MRI) contrast agent that carries cyclen-based macrocyclic chelates coordinating paramagnetic gadolinium ions. In a series of MRI experiments in vitro, this agent produced an amplified MRI signal when compared to the commercially available monomeric analogue.

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Neuroscience

Real-Time fMRI Brain Mapping in Animals
Sangcheon Choi 1,2, Kengo Takahashi 1,2, Yuanyuan Jiang 1,3, Sascha Köhler 4, Hang Zeng 1,2, Qi Wang 1,2, Yan Ma 1,2, Xin Yu 1,3
1Max Planck Institute for Biological Cybernetics, 2Graduate Training Centre of Neuroscience, 3MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Harvard Medical School, Massachusetts General Hospital, 4Bruker BioSpin

Animal brain functional mapping can benefit from the real-time functional magnetic resonance imaging (fMRI) experimental set-up. Using the latest software implemented in the animal MRI system, we established a real-time monitoring platform for small animal fMRI.

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Cancer Research

Characterization and Functional Prediction of Bacteria in Ovarian Tissues
Lanbo Zhao *1, Weichu Zhao *2, Qi Wang *1, Dongxin Liang 1, Yu Liu 3, Guoxing Fu 4, Lu Han 1, Yiran Wang 1, Chao Sun 1, Qing Wang 1, Qing Song 1, Qiling Li 1, Qinrui Lu 1
1Department of Obstetrics and Gynecology, First Affiliated Hospital of Xi’an Jiaotong University, 2School of Social Sciences, University of Manchester, 3Department of Pathology, First Affiliated Hospital of Xi’an Jiaotong University, 4Omega Bioservices Inc

Immunohistochemistry staining and 16S ribosomal RNA gene (16S rRNA gene) sequencing were performed in order to discover and distinguish bacteria in cancerous and noncancerous ovarian tissues in situ. The compositional and functional differences of the bacteria were predicted by using BugBase and Phylogenetic Investigation of Communities by Reconstruction of Unobserved States (PICRUSt).

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Medicine

Augmented Reality Navigation-Guided Core Decompression for Osteonecrosis of Femoral Head
Qi Wang *1,3, Qiuyuan Wang *2,3, Ran Ding 3, Youjie Yao 4, Junjun Pan 5, Weiguo Wang 3
1China-Japan Friendship School of Clinical Medicine, Peking University, 2Graduate School of Beijing University of Chinese Medicine, 3Department of Orthopedic Surgery, Beijing Key Lab of Immunes-Mediated Inflammatory Disease, China-Japan Friendship Hospital, 4Beijing Normal University, 5State Key Laboratory of Virtual Reality Technology and Systems, Beihang University

Augmented reality technology was applied to core decompression for osteonecrosis of the femoral head to realize real-time visualization of this surgical procedure. This method can effectively improve the safety and precision of core decompression.

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Cancer Research

Surgical Technique for Superior Cervical Ganglionectomy in a Murine Model
Qi Wang 1, Chun-Hao Chen 1, Hongbo Xu 2, Sylvie Deborde 1,3, Richard J. Wong 1,3
1Department of Surgery, Memorial Sloan Kettering Cancer Center, 2Department of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, 3David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center

The present protocol describes a mouse model of the ablation of adrenergic innervation by identifying and resecting the superior cervical ganglion.

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