CFD RESEARCH CORPORATION

2 ARTICLES PUBLISHED IN JoVE

Bioengineering

Generation of Shear Adhesion Map Using SynVivo Synthetic Microvascular Networks

Ashley M. Smith¹, Balabhaskar Prabhakarpandian¹, Kapil Pant¹

¹Biomedical Technology, CFD Research Corporation

Flow chambers used in adhesion experiments typically consist of linear flow paths and require multiple experiments at different flow rates to generate a shear adhesion map. SynVivo-SMN enables the generation of shear adhesion map using a single experiment utilizing microliter volumes resulting in significant savings in time and consumables.

Bioengineering

A Microphysiological System to Study Leukocyte-Endothelial Cell Interaction during Inflammation

Qingliang Yang¹, Jordan C. Langston², Yuan Tang³, Balabhaskar Prabhakarpandian⁴, Laurie E. Kilpatrick⁵, Mohammad F. Kiani^1,2,6

¹Department of Mechanical Engineering, Temple University, ²Department of Bioengineering, Temple University, ³Department of Bioengineering, University of Toledo, ⁴Biomedical Technology, CFD Research Corporation, ⁵Center for Inflammation and Lung Research, Department of Microbiology, Immunology and Inflammation, Lewis Katz School of Medicine, Temple University, ⁶Department of Radiation Oncology, Lewis Katz School of Medicine, Temple University

In this protocol, a biomimetic microfluid assay, which can reproduce a physiologically relevant microvascular environment and reproduce the entire leukocyte adhesion/migration cascade, is employed to study leukocyte-endothelial cell interactions in inflammatory disease.