A Rabbit Aortic Valve Stenosis Model Induced by Direct Balloon InjuryEunmin Kim *1, Eun-Hye Park *1, Jin-Moo Kim 1, Eunmi Lee 1, Sin-Hee Park 1, Chan Woo Kim 1, Ik Jun Choi 1,2, Min-ho Oak 3, Kiyuk Chang 1,4
1Cardiovascular Research Institute for Intractable Disease, College of Medicine, The Catholic University of Korea, 2Division of Cardiology, Incheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, 3College of Pharmacy and Natural Medicine Research Institute, Mokpo National University, 4Division of Cardiology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea
An appropriate animal model is needed to understand the pathologic mechanisms underlying aortic valve stenosis (AVS) and to evaluate the efficacy of therapeutic interventions. The present protocol describes a new procedure for developing the AVS rabbit model via a direct balloon injury in vivo.
