Fundação Oswaldo Cruz

1 ARTICLES PUBLISHED IN JoVE

Immunology and Infection

In Vitro Assay of Plasmodium-Infected Red Blood Cell Killing by Cytotoxic Lymphocytes

Luna de Lacerda^*1, Guilherme Castro^*1,2, Cristopher Gomes¹, Caroline Junqueira¹

¹Instituto René Rachou, Fundação Oswaldo Cruz, ²Departamento de Bioquímica e Imunologia, Universidade Federal de Minas Gerais

Here we describe a new method to help elucidate the mechanisms of cellular immunity to Plasmodium during the blood stage of infection. This is an in vitro assay that measures infected red blood cell killing by cytotoxic lymphocytes.