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University of Texas Medical Branch at Galveston

3 ARTICLES PUBLISHED IN JoVE

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Neuroscience

Automated Gait Analysis in Mice with Chronic Constriction Injury
Dong-Wook Kang 1, Jae-Gyun Choi 1, Ji-Young Moon 2, Suk-Yun Kang 2, Yeonhee Ryu 2, Jin Bong Park 1, Hyun-Woo Kim 1,3
1Department of Physiology and Medical Science, College of Medicine and Brain Research Institute, Chungnam National University, 2KM Fundamental Research Division, Korea Institute of Oriental Medicine (KIOM), 3Department of Neuroscience and Cell Biology, University of Texas Medical Branch at Galveston

The precise assessment of pain response in a neuropathic animal model is critical to investigate the pathophysiology of pain diseases and develop new analgesics. We present a sensitive and objective method to determine the sensory function of the rodent hind paw by an automated gait analysis system.

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Immunology and Infection

Rapid, Seamless Generation of Recombinant Poxviruses using Host Range and Visual Selection
Sameera Vipat *1, Greg Brennan *1, Chorong Park 1, Sherry L. Haller 2, Stefan Rothenburg 1
1Department of Medial Microbiology and Immunology, School of Medicine, University of California Davis, 2Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston

This is a method to generate “scarless” recombinant vaccinia viruses using host-range selection and visual identification of recombinant viruses.

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Immunology and Infection

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model
Ying Xiao 1,2, Xiaoying S Zhong 1, Xiaowei Liu 2, Qingjie Li 1
1Division of Gastroenterology, Department of Internal Medicine, University of Texas Medical Branch at Galveston, 2Department of Gastroenterology, Xiangya Hospital of Central South University

The interaction of genetic susceptibility, mucosal immunity, and intestinal microecological environment is involved in the pathogenesis of inflammatory bowel disease (IBD). In this study, we applied fecal microbiota transplantation to IL-10 deficient mice and investigated its impact on colonic inflammation and heart function.

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