Genetic Studies of Human DNA Repair Proteins Using Yeast as a Model System Monika Aggarwal 1, Robert M. Brosh Jr. 1
1Laboratory of Molecular Gerontology, National Institute on Aging, NIH
Genetic studies in yeast can be employed to investigate the molecular and cellular functions of human genes in cellular DNA metabolism. Methods are described for the genetic characterization of the human WRN gene product defective in the premature aging disorder Werner syndrome in functionally conserved pathways using yeast as a tractable model system.
