University College Hospital

2 ARTICLES PUBLISHED IN JoVE

Neuroscience

Electrophysiological Measurements and Analysis of Nociception in Human Infants

L. Fabrizi^*1, A. Worley^*2, D. Patten¹, S. Holdridge¹, L. Cornelissen¹, J. Meek³, S. Boyd², R. Slater^1,4

¹Neuroscience, Physiology and Pharmacology, University College London, ²Department of Clinical Neurophysiology, Great Ormond Street Hospital, ³Elizabeth Garrett Anderson Obstetric Hospital, University College Hospital, ⁴Nuffield Department of Anaesthetics, University of Oxford

The assessment and treatment of pain in infants is difficult because infants cannot verbally report their experience. In this video we describe quantitative electrophysiological methods and analysis techniques that can be used to measure the response to noxious events from the infant nervous system.

Engineering

Three-Dimensional Ultrasonic Needle Tip Tracking with a Fiber-Optic Ultrasound Receiver

Wenfeng Xia^1,2, Simeon J. West³, Malcolm C. Finlay^2,4, Rosalind Pratt^5,6, Sunish Mathews^1,2, Jean-Martial Mari⁷, Sebastien Ourselin^1,2,6, Anna L. David^1,5,8,9, Adrien E. Desjardins^1,2

¹Wellcome/EPSRC Centre for Interventional and Surgical Sciences, University College London, ²Department of Medical Physics and Biomedical Engineering, University College London, ³Department of Anaesthesia, University College Hospital, ⁴St Bartholomew's Hospital and Queen Mary University of London, ⁵Institute for Women's Health, University College London, ⁶Centre for Medical Imaging Computing, University College London, ⁷GePaSud, University of French Polynesia, ⁸Department of Development and Regeneration, KU Leuven (Katholieke Universiteit), ⁹NIHR University College London Hospitals Biomedical Research Centre

Accurate and efficient visualization of invasive medical devices is extremely important in many ultrasound-guided minimally invasive procedures. Here, a method for localizing the spatial position of a needle tip relative to the ultrasound imaging probe is presented.