Lung Fixation under Constant Pressure for Evaluation of Emphysema in MiceKeiko Karasutani 1,2, Hario Baskoro 1, Tadashi Sato 1, Naoko Arano 1, Yohei Suzuki 1, Aki Mitsui 1, Naoko Shimada 1, Yuzo Kodama 1, Kuniaki Seyama 1, Yoshinosuke Fukuchi 1, Kazuhisa Takahashi 1
1Department of Respiratory Medicine, Juntendo University Graduate School of Medicine, Juntendo University, 2Pharmaceutical Planning Group, Otsuka Pharmaceutical Co., Ltd.
Presented here is a useful protocol for lung fixation that creates a stable condition for histological evaluate of lung specimens from a mouse model of emphysema. The main advantage of this model is that it can fix many lungs with the same constant pressure without lung collapse or deflation.
