National Cerebral and Cardiovascular Center

1 ARTICLES PUBLISHED IN JoVE

Neuroscience

A Rat Model of Mild Intrauterine Hypoperfusion with Microcoil Stenosis

Masahiro Tsuji¹, Jacques-Olivier Coq², Yuko Ogawa¹, Yumi Yamamoto¹, Makiko Ohshima¹

¹Department of Regenerative Medicine and Tissue Engineering, National Cerebral and Cardiovascular Center, ²Institut de Neurosciences de la Timone, CNRS, Aix Marseille Université

Mild intrauterine hypoperfusion was produced by artery stenosis with metal microcoils wrapped around the uterine and ovarian arteries in rats at embryonic day 17. This procedure produced prenatal hypoperfusion and intrauterine growth restriction.