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NeuroNexus Technologies

3 ARTICLES PUBLISHED IN JoVE

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Neuroscience

Whole Animal Perfusion Fixation for Rodents
Gregory J. Gage 1, Daryl R. Kipke 1, William Shain 2
1Biomedical Engineering, University of Michigan , 2Department of Neurological Surgery, University of Washington School of Medicine

Here we describe a low-cost, rapid, controlled and uniform fixation procedure using 4% paraformaldehyde perfused via the vascular system: through the heart of the rat to obtain the best possible preservation of the brain.

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Neuroscience

Surgical Implantation of Chronic Neural Electrodes for Recording Single Unit Activity and Electrocorticographic Signals
Gregory J. Gage 1, Colin R. Stoetzner 1, Thomas Richner 2, Sarah K. Brodnick 2, Justin C. Williams 2, Daryl R. Kipke 1,3
1Biomedical Engineering, University of Michigan , 2Biomedical Engineering, University of Wisconsin-Madison, 3NeuroNexus Technologies

We provide useful information for surgeons who are learning the process of implanting chronic neural recording electrodes. Techniques for both penetrating and surface electrode systems are described in a rodent animal model.

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Education

Voltage Biasing, Cyclic Voltammetry, & Electrical Impedance Spectroscopy for Neural Interfaces
Seth J. Wilks 1, Tom J. Richner 2, Sarah K. Brodnick 2, Daryl R. Kipke 3, Justin C. Williams 2, Kevin J. Otto 1,4
1Weldon School of Biomedical Engineering, Purdue University, 2Biomedical Engineering, University of Wisconsin-Madison, 3Biomedical Engineering, University of Michigan , 4Department of Biological Sciences, Purdue University

The electrode-tissue interface of neural recording electrodes can be characterized with electrical impedance spectroscopy (EIS) and cyclic voltammetry (CV). Application of voltage biasing changes the electrochemical properties of the electrode-tissue interface and can improve recording capability. Voltage biasing, EIS, CV, and neural recordings are complementary.

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