NeuroNexus Technologies

3 ARTICLES PUBLISHED IN JoVE

Neuroscience

Whole Animal Perfusion Fixation for Rodents

Gregory J. Gage¹, Daryl R. Kipke¹, William Shain²

¹Biomedical Engineering, University of Michigan , ²Department of Neurological Surgery, University of Washington School of Medicine

Here we describe a low-cost, rapid, controlled and uniform fixation procedure using 4% paraformaldehyde perfused via the vascular system: through the heart of the rat to obtain the best possible preservation of the brain.

Neuroscience

Surgical Implantation of Chronic Neural Electrodes for Recording Single Unit Activity and Electrocorticographic Signals

Gregory J. Gage¹, Colin R. Stoetzner¹, Thomas Richner², Sarah K. Brodnick², Justin C. Williams², Daryl R. Kipke^1,3

¹Biomedical Engineering, University of Michigan , ²Biomedical Engineering, University of Wisconsin-Madison, ³NeuroNexus Technologies

We provide useful information for surgeons who are learning the process of implanting chronic neural recording electrodes. Techniques for both penetrating and surface electrode systems are described in a rodent animal model.

Education

Voltage Biasing, Cyclic Voltammetry, & Electrical Impedance Spectroscopy for Neural Interfaces

Seth J. Wilks¹, Tom J. Richner², Sarah K. Brodnick², Daryl R. Kipke³, Justin C. Williams², Kevin J. Otto^1,4

¹Weldon School of Biomedical Engineering, Purdue University, ²Biomedical Engineering, University of Wisconsin-Madison, ³Biomedical Engineering, University of Michigan , ⁴Department of Biological Sciences, Purdue University

The electrode-tissue interface of neural recording electrodes can be characterized with electrical impedance spectroscopy (EIS) and cyclic voltammetry (CV). Application of voltage biasing changes the electrochemical properties of the electrode-tissue interface and can improve recording capability. Voltage biasing, EIS, CV, and neural recordings are complementary.