University of Pavia
3 ARTICLES PUBLISHED IN JoVE
Medicine
Orthotopic Liver Transplantation in Rats
Graziano Oldani 1,2, Stephanie Lacotte 3, Philippe Morel 4, Gilles Mentha 1, Christian Toso 1
1Transplantation Division, Department of Surgery, University of Geneva Hospitals, 2Department of Surgery, University of Pavia , 3Department of Surgery, University of Geneva, 4Division of Abdominal Surgery, Department of Surgery, University of Geneva Hospitals
We present an easy-to-establish revision of the classical two-cuff technique for orthotopic liver transplantation in rat.
Bioengineering
Manufacturing Devices and Instruments for Easier Rat Liver Transplantation
Graziano Oldani 1,2, Stephanie Lacotte 3, Lorenzo Orci 1, Philippe Morel 4, Gilles Mentha 1, Christian Toso 1
1Transplantation Division, Department of Surgery, University of Geneva Hospitals, 2Department of Surgery, University of Pavia , 3Department of Surgery, University of Geneva, 4Division of Abdominal Surgery, Department of Surgery, University of Geneva Hospitals
We describe the design of the “quick-linker” device for easier orthotopic rat liver transplantation.
Medicine
Reduced Complications after Arterial Reconnection in a Rat Model of Orthotopic Liver Transplantation
Xu-Chun Chen *1, Manmeet Sekhon *1,2, Xue-Zhong Ma *1, Justin Manuel 1, Sai Chung 1,2, Eddie He 1, Agata Bartczak 1, Sandra Fischer 3, Cornelia Thoeni 3, Graziano Oldani 1, Catia T. Perciani 1, Sonya MacParland 1,2,3, Ian McGilvray 1
1Multi-Organ Transplant Program, University Health Network, 2Department of Immunology, University of Toronto, 3Department of Laboratory Medicine and Pathobiology, University of Toronto
The goal of this study is to modify the rat orthotopic liver transplant model to better represent human liver transplantation and improve recipient survival. The presented method reestablishes hepatic arterial inflow by connecting the donor liver's common hepatic artery to the recipient liver's proper hepatic artery.
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