University of Pavia

3 ARTICLES PUBLISHED IN JoVE

Medicine

Orthotopic Liver Transplantation in Rats

Graziano Oldani^1,2, Stephanie Lacotte³, Philippe Morel⁴, Gilles Mentha¹, Christian Toso¹

¹Transplantation Division, Department of Surgery, University of Geneva Hospitals, ²Department of Surgery, University of Pavia , ³Department of Surgery, University of Geneva, ⁴Division of Abdominal Surgery, Department of Surgery, University of Geneva Hospitals

We present an easy-to-establish revision of the classical two-cuff technique for orthotopic liver transplantation in rat.

Bioengineering

Manufacturing Devices and Instruments for Easier Rat Liver Transplantation

Graziano Oldani^1,2, Stephanie Lacotte³, Lorenzo Orci¹, Philippe Morel⁴, Gilles Mentha¹, Christian Toso¹

We describe the design of the “quick-linker” device for easier orthotopic rat liver transplantation.

Medicine

Reduced Complications after Arterial Reconnection in a Rat Model of Orthotopic Liver Transplantation

Xu-Chun Chen^*1, Manmeet Sekhon^*1,2, Xue-Zhong Ma^*1, Justin Manuel¹, Sai Chung^1,2, Eddie He¹, Agata Bartczak¹, Sandra Fischer³, Cornelia Thoeni³, Graziano Oldani¹, Catia T. Perciani¹, Sonya MacParland^1,2,3, Ian McGilvray¹

¹Multi-Organ Transplant Program, University Health Network, ²Department of Immunology, University of Toronto, ³Department of Laboratory Medicine and Pathobiology, University of Toronto

The goal of this study is to modify the rat orthotopic liver transplant model to better represent human liver transplantation and improve recipient survival. The presented method reestablishes hepatic arterial inflow by connecting the donor liver's common hepatic artery to the recipient liver's proper hepatic artery.