St. John-Providence Health System

1 ARTICLES PUBLISHED IN JoVE

Immunology and Infection

Overcoming Unresponsiveness in Experimental Autoimmune Encephalomyelitis (EAE) Resistant Mouse Strains by Adoptive Transfer and Antigenic Challenge

Michael K. Shaw¹, Xiao-qing Zhao², Harley Y. Tse²

¹Department of Medicine, Section of Cardiology, St. John-Providence Health System, ²Department of Immunology and Microbiology, Wayne State University School of Medicine

Certain mouse strains are able to resist induction of experimental autoimmune encephalomyelitis (EAE) with myelin basic protein. Described here is a simple immunization protocol that reverses the unresponsiveness and induces paralytic disease in several typical EAE resistant mouse stains.