The Warren Alpert Brown Medical School of Brown University and the Rhode Island Hospital

1 ARTICLES PUBLISHED IN JoVE

JoVE Core

Design of a Biaxial Mechanical Loading Bioreactor for Tissue Engineering

Bahar Bilgen^1,2, Danielle Chu³, Robert Stefani¹, Roy K. Aaron^1,2

¹Department of Orthopaedics, The Warren Alpert Brown Medical School of Brown University and the Rhode Island Hospital, ²Center for Restorative and Regenerative Medicine, VA Medical Center, Providence, RI, ³University of Texas Southwestern Medical Center

We designed a novel mechanical loading bioreactor that can apply uniaxial or biaxial mechanical strain to a cartilage biocomposite prior to transplantation into an articular cartilage defect.