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Cascade LifeSciences Inc.

1 ARTICLES PUBLISHED IN JoVE

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Bioengineering

A Novel Three-dimensional Flow Chamber Device to Study Chemokine-directed Extravasation of Cells Circulating under Physiological Flow Conditions
Valentina Goncharova 1, Sophia K. Khaldoyanidi 1,2
1Torrey Pines Institute for Molecular Studies, 2Cascade LifeSciences Inc.

The three-dimensional flow chamber device is a novel in vitro technology for the quantitative and step-wise evaluation of the extravasation cascade of cells circulating under conditions of physiological shear stress. The device therefore fills a critical need for basic, preclinical, and clinical studies of cell migration.

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