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Seoul National University bundang hospital

9 ARTICLES PUBLISHED IN JoVE

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Behavior

Neuronavigation-guided Repetitive Transcranial Magnetic Stimulation for Aphasia
Woo-Jin Kim 1, Soo Jung Hahn 2, Won-Seok Kim 2, Nam-Jong Paik 2
1Department of Rehabilitation Medicine, Inje University of Medicine, Haeundae Paik Hospital, 2Department of Rehabilitation Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital

This study is designed to test the hypothesis that neuronavigational system-guided transcranial magnetic stimulation has higher accuracy for targeting the intended target as demonstrated by eliciting a greater degree of virtual aphasia in healthy subjects, measured by delay in reaction time to picture naming.

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Medicine

Use of Rabbit Eyes in Pharmacokinetic Studies of Intraocular Drugs
Seong Joon Ahn 1,2,3, Hye Kyoung Hong 1, Young Mi Na 1, Sang Jun Park 1,2, Jeeyun Ahn 1,2,4, Jaeseong Oh 5, Jae Yong Chung 6, Kyu Hyung Park 1,2, Se Joon Woo 1,2
1Department of Ophthalmology, Seoul National University Bundang Hospital, 2Department of Ophthalmology, College of Medicine, Seoul National University, 3Department of Ophthalmology, Hanyang University Hospital, 4Department of Ophthalmology, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, 5Department of Clinical Pharmacology, Seoul National University Hospital, 6Department of Clinical Pharmacology, Seoul National University Bundang Hospital

Rabbits are widely used to study the pharmacokinetics of intraocular drugs. We describe a method for conducting pharmacokinetic studies of intraocular drugs using rabbit eyes.

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Cancer Research

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles
Ji-Eun Chang 1, Hyun-Jong Cho 2, Sanghoon Jheon 1,3
1Department of Thoracic and Cardiovascular Surgery, Seoul National University Bundang Hospital, 2College of Pharmacy, Kangwon National University, 3Department of Thoracic and Cardiovascular Surgery, Seoul National University College of Medicine

Photodynamic therapy (PDT) is an alternative choice for lung cancer treatment. To increase the therapeutic effect of PDT, lung cancer-targeted nanoparticles combined with chemotherapy were developed. Both in vitro and in vivo anticancer efficacies of PDT with prepared nanoparticles were evaluated.

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Behavior

Mobile Game-based Virtual Reality Program for Upper Extremity Stroke Rehabilitation
Yoon-Hee Choi 1,2, Nam-Jong Paik 1
1Department of Rehabilitation Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, 2Department of Physical Medicine and Rehabilitation, Soonchunhyang University College of Medicine, Soonchunhyang University Hospital

Here, we present a protocol to develop and apply a mobile game-based virtual reality program for the recovery of upper limb dysfunction in patients with stroke. The present study shows that the mobile program is feasible and effectively promotes upper limb recovery in stroke patients.

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Bioengineering

Isokinetic Robotic Device to Improve Test-Retest and Inter-Rater Reliability for Stretch Reflex Measurements in Stroke Patients with Spasticity
Minki Sin *1, Won-Seok Kim *2, Kyujin Cho 3, Nam-Jong Paik 2
1Department of Medical Assistant Robot, Daegu Research Center, Korea Institute of Machinery & Materials, 2Department of Rehabilitation Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, 3School of Mechanical and Aerospace Engineering, Seoul National University/IAMD

Using a robotic isokinetic device with electromyography (EMG) measurements, this protocol illustrates that isokinetic motion itself can improve inter-rater reliability for the angle of catch measurements in stroke patients with mild elbow flexor spasticity.

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Medicine

Virtual Prism Adaptation Therapy: Protocol for Validation in Healthy Adults
Sungmin Cho *1, Won-Seok Kim *2, Seo Hyun Park 2, Jihong Park 2, Nam-Jong Paik 2
1Delvine Inc., 2Department of Rehabilitation Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital

This experimental protocol demonstrates the use of virtual prism adaptation therapy (VPAT) in healthy adults and the association between VPAT and functional near infrared spectroscopy to determine the effect of VPAT on cortical activation. Results suggest that VPAT may be feasible and could induce similar behavioral adaptation as conventional prism adaptation therapy.

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Medicine

Stabilized Longitudinal In Vivo Cellular-Level Visualization of the Pancreas in a Murine Model with a Pancreatic Intravital Imaging Window
Inwon Park 1, Pilhan Kim 2,3
1Department of Emergency Medicine, Seoul National University Bundang Hospital, 2Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, 3KI for Health Science and Technology, Korea Advanced Institute of Science and Technology

In vivo high-resolution imaging of the pancreas was facilitated with the pancreatic intravital imaging window.

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Neuroscience

Electroencephalography Network Indices as Biomarkers of Upper Limb Impairment in Chronic Stroke
Ga-Young Choi *1, Won Kee Chang *2, Miseon Shim 1, Nuri Kim 2, Ji-hee Jang 2, Won-Seok Kim 2, Han-Jeong Hwang 1,3, Nam-Jong Paik 2
1Department of Electronics and Information Engineering, Korea University, 2Department of Rehabilitation Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, 3Interdisciplinary Graduate Program for Artificial Intelligence Smart Convergence Technology, Korea University

The experimental protocol demonstrates the paradigm for acquiring and analyzing electroencephalography (EEG) signals during upper limb movement in individuals with stroke. The alteration of the functional network of low-beta EEG frequency bands was observed during the movement of the impaired upper limb and was associated with the degree of motor impairment.

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Medicine

Reliability of Artificial Intelligence-Based Cone Beam Computed Tomography Integration with Digital Dental Images
Ju-Heon Lee *1, Nam-Ki Lee *1, Bingshuang Zou 2, Jae Hyun Park 3,4, Tae-Hyun Choi 1
1Department of Orthodontics, Seoul National University Bundang Hospital, 2Division of Orthodontics, Faculty of Dentistry, University of British Columbia, 3Postgraduate Orthodontic Program, Arizona School of Dentistry & Oral Health, A. T. Still University, 4Graduate School of Dentistry, Kyung Hee University

A process of registering cone-beam computed tomography scans and digital dental images has been presented using artificial intelligence (AI) -assisted identification of landmarks and merging. A comparison with surface-based registration shows that AI-based digitization and integration are reliable and reproducible.

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