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2 ARTICLES PUBLISHED IN JoVE

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Immunology and Infection

Development and Validation of an Ultrasensitive Single Molecule Array Digital Enzyme-linked Immunosorbent Assay for Human Interferon-α
Alba Llibre *1,2, Vincent Bondet *1,2, Mathieu P. Rodero 3, David Hunt 4, Yanick J. Crow 3,5, Darragh Duffy 1,2
1Immunobiology of Dendritic Cells, Institut Pasteur, 2INSERM U1223, 3Laboratory of Neurogenetics and Neuroinflammation, INSERM UMR1163, Institut Imagine, 4MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, 5Manchester Centre for Genomic Medicine, University of Manchester

Here we present a protocol to describe the development and validation of a single molecule array digital ELISA assay, which enables the ultra-sensitive detection of all IFN-α subtypes in human samples.

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Neuroscience

Behavioral And Physiological Analysis In A Zebrafish Model Of Epilepsy
Hortense de Calbiac *1,2, Adriana Dabacan *3, Raul Muresan 3, Edor Kabashi 1,2, Sorana Ciura 1,2
1University Paris Descartes Hospital Necker-Enfants Malades, Institut Imagine, 2Institut du Cerveau et de la Moelle épinière - ICM, Sorbonne Universités Paris, 3Transylvanian Institute of Neuroscience (TINS)

Here, we present a protocol for the development and the characterization of a zebrafish model of epilepsy resulting from the transient inhibition of the DEPDC5 gene.

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