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Johannes Gutenberg University Medical Center

2 ARTICLES PUBLISHED IN JoVE

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Virus-induced Gene Knockdown in the CA3 and Subsequent Spatial Relocation Test to Assess CA3-dependent Cognitive Function
Mercè Masana 1,2, Ulrich Schmitt 1, Konstantin Radyushkin 3, Andrés Uribe-Mariño 2, Marianne B Müller 1,2
1Department of Psychiatry and Psychotherapy & Focus Program Translational Neuroscience (FTN), Johannes Gutenberg University Medical Center, 2Max-Planck Institute of Psychiatry, 3Focus Program Translational Neurosciences (FTN), Johannes Gutenberg University of Mainz

Hippocampal cognitive function can be modulated by locally manipulating gene expression. The spatial object relocation test is a short and robust spatial memory test. We combined this test with virus-induced manipulation of gene expression in the CA3 region to assess the impact of the target gene in shaping cognitive performance.

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Behavior

Social Threat-Safety Test Uncovers Psychosocial Stress-Related Phenotypes
Sarah Ayash 1, Marianne Müller 1,2, Ulrich Schmitt 1
1Leibniz-Institute for Resilience Research, 2Translational Psychiatry, Department of Psychiatry and Psychotherapy, Johannes Gutenberg University Medical Center

The social threat-safety test allows a simultaneous assessment of social avoidance development as a measurement of aversive conditioned learning and social threat-safety discrimination ability, both utilized to identify stress-susceptible and stress-resilient individuals within a single group of chronically socially defeated male mice.

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