Hippocampal cognitive function can be modulated by locally manipulating gene expression. The spatial object relocation test is a short and robust spatial memory test. We combined this test with virus-induced manipulation of gene expression in the CA3 region to assess the impact of the target gene in shaping cognitive performance.
The social threat-safety test allows a simultaneous assessment of social avoidance development as a measurement of aversive conditioned learning and social threat-safety discrimination ability, both utilized to identify stress-susceptible and stress-resilient individuals within a single group of chronically socially defeated male mice.
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