Shriners Burn Institute

2 ARTICLES PUBLISHED IN JoVE

Neuroscience

Magnetic Resonance Spectroscopy of live Drosophila melanogaster using Magic Angle Spinning

Valeria Righi^1,2,3, Yiorgos Apidianakis^2,4, Laurence G. Rahme^2,4, A. Aria Tzika^1,2,3

¹NMR Surgical Laboratory, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, ²Shriners Burn Institute, ³Department of Radiology, Athinoula A. Martinos Center of Biomedical Imaging, Harvard Medical School, ⁴Molecular Surgery Laboratory, Department of Surgery, Massachusetts General Hospital, Harvard Medical School

This technique enables the use of high-resolution magic angle spinning proton MR spectroscopy (HRMAS 1H-MRS) for molecular characterization of live Drosophila melanogaster with a conventional 14.1 tesla spectrometer equipped with an HRMAS probe.

JoVE Core

Functional MRI in Conjunction with a Novel MRI-compatible Hand-induced Robotic Device to Evaluate Rehabilitation of Individuals Recovering from Hand Grip Deficits

Mark P. Ottensmeyer^1,2, Shasha Li^2,3,4, Gianluca De Novi^1,2, A. Aria Tzika^2,3,4

¹Medical Device & Simulation Laboratory, Department of Radiology, Massachusetts General Hospital, ²Harvard Medical School, ³NMR Surgical Laboratory, Department of Surgery, Center for Surgery, Innovation and Bioengineering, Massachusetts General Hospital, Harvard Medical School, ⁴Athinoula A. Martinos Center of Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School

We performed functional MRI using a novel MRI-compatible hand-induced robotic device to evaluate its utility for monitoring hand motor function in individuals recovering from neurological deficits.