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Yonsei University Wonju College of Medicine

3 ARTICLES PUBLISHED IN JoVE

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Neuroscience

Neurobehavioral Assessments in a Mouse Model of Neonatal Hypoxic-ischemic Brain Injury
MinGi Kim 1,2, Ji Hea Yu 1, Jung Hwa Seo 1,2, Yoon-Kyum Shin 1,2, Soohyun Wi 1,2, Ahreum Baek 1,3, Suk-Young Song 1,5, Sung-Rae Cho 1,2,4,5
1Department and Research Institute of Rehabilitation Medicine, Yonsei University College of Medicine, 2Brain Korea 21 PLUS Project for Medical Science, Yonsei University, 3Department of Rehabilitation Medicine, Yonsei University Wonju College of Medicine, 4Rehabilitation Institute of Neuromuscular Disease, Yonsei University College of Medicine, 5Graduate Program of NanoScience and Technology, Yonsei University

We performed unilateral carotid artery occlusion on postnatal day 7-10 CD-1 mouse pups to create a neonatal hypoxic-ischemic (HI) model and investigated the effects of HI brain injury. We studied neurobehavioral functions in these mice compared to non-operated normal mice.

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Medicine

In vitro Time-lapse Live-Cell Imaging to Explore Cell Migration toward the Organ of Corti
Jeong-Eun Park *1,2,3, Su Hoon Lee *1,2, Dong Jun Park 1,2, Young Joon Seo 1,2, Sung Kyun Kim 3
1Department of Otorhinolaryngology, Yonsei University Wonju College of Medicine, 2Research Institute of Hearing Enhancement, Yonsei University Wonju College of Medicine, 3Department of Otorhinolaryngology Head and Neck Surgery, Hallym University College of Medicine

In this study, we present a real-time imaging method using confocal microscopy to observe cells moving toward damaged tissue by ex vivo incubation with the cochlear epithelium containing the organ of Corti.

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Behavior

A Smartphone-Based Imaging Method for C. elegans Lawn Avoidance Assay
Saebom Kwon 1, Jin I. Lee 2, Kyoung-hye Yoon 1
1Department of Physiology, Mitohormesis Research Center, Yonsei University Wonju College of Medicine, 2Division of Biological Science and Technology, College of Science and Technology, Yonsei University, Mirae Campus

This article describes a simple, low-cost method of recording the lawn avoidance behavior of Caenorhabditis elegans, using readily available items such as a smartphone and a light emitting diode (LED) light box. We also provide a Python script to process the video file into a format more amenable for counting.

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