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Molecular Medicine Research Institute

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JoVE Journal

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
Shanmugavel Madasamy 1, David Liu 1, Jason Lundry 1, Benjamin Alderete 2, Raymond Kong 2, J. Paul Robinson 3, Alan H.B. Wu 1,4, Edward P. Amento 5
1Plaxgen Inc, 2Millipore Sigma, 3Cytometry Laboratories, Purdue University, 4San Francisco General Hospital, 2M16 Clinical Chemistry, University of California, San Francisco, 5Molecular Medicine Research Institute

The objective of this study was to evaluate in vitro lipid-lowering drug effects in modulating the morphology of cholesterol particles. Comparison of lipid-lowering drugs revealed variations in their effect in modulating the morphological features of cholesterol particles.

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