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Università Cattolica del Sacro Cuore

3 ARTICLES PUBLISHED IN JoVE

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Biology

The use of Biofeedback in Clinical Virtual Reality: The INTREPID Project
Claudia Repetto 1, Alessandra Gorini 1, Cinzia Vigna 1, Davide Algeri 1, Federica Pallavicini 1, Giuseppe Riva 1,2
1Applied Technology for Neuro-Psychology Lab, Istituto Auxologico Italiano, 2Psychology Department, Università Cattolica del Sacro Cuore

The Project on Virtual Reality Intelligent Multi-sensor System for the Treatment of Anxiety-related Disorders (INTREPID) is aimed at developing a multi-sensor context-aware virtual reality system for the treatment of anxiety-related disorders.

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Immunology and Infection

Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments
Adele De Ninno 1, Francesca Romana Bertani 1, Annamaria Gerardino 1, Giovanna Schiavoni 2, Martina Musella 3, Claudia Galassi 3, Fabrizio Mattei 2, Antonella Sistigu 3,4, Luca Businaro 1
1CNR Institute for Photonics and Nanotechnology, 2Dept. of Oncology and Molecular Medicine, Istituto Superiore di Sanità, 3Istituto di Patologia Generale, Università Cattolica del Sacro Cuore, 4Tumor Immunology and Immunotherapy Unit, IRCCS Regina Elena National Cancer Institute

In the age of immunotherapy and single-cell genomic profiling, cancer biology requires novel in vitro and computational tools for investigating the tumor-immune interface in a proper spatiotemporal context. We describe protocols to exploit tumor-immune microfluidic co-cultures in 2D and 3D settings, compatible with dynamic, multiparametric monitoring of cellular functions.

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Cancer Research

Co-Culture In Vitro Systems to Reproduce the Cancer-Immunity Cycle
Nicoletta Manduca *1, Ester Maccafeo *1, Adele De Ninno 2, Antonella Sistigu 1,3, Martina Musella 1
1Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, 2CNR Institute for Photonics and Nanotechnology, 3Fondazione Policlinico Universitario ‘A. Gemelli’ - IRCCS

Here, we detail a simple, fast, and reliable multiparametric flow cytometry- and tumor-on-a-chip-assisted protocol to monitor and characterize the steps constituting the cancer-immunity cycle. Indeed, a thorough understanding of the interplays between cancer and immune cells provides critical insights to outsmart tumors and guide clinical care.

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