Second Affiliated Hospital of Nanjing Medical University

4 ARTICLES PUBLISHED IN JoVE

Neuroscience

Sub-acute Cerebral Microhemorrhages Induced by Lipopolysaccharide Injection in Rats

Dandan Li^*1,2, Hóngyi Zhào^*2,3, Wei Wei², Nan Liu², Yonghua Dr. Huang²

¹Department of Neurology, Second Hospital of Shanxi Medical University, ²Department of Neurology, PLA Army General Hospital, ³Department of Neurology, NO 261 Hospital of PLA

We present a protocol to induce and detect CMHs caused by LPS injection in Sprague-Dawley rats, which may be utilized in future research investigations on the pathogenesis of CMHs.

A Rat Model of Radiation Vasculitis for Mesenchymal Stem Cell-based Therapy

Xuan Tao^*1, Mingyang Sun^*1, Rongchao Ying², Wenjie Su², Wei Wei¹, Xiaohu Meng¹

¹Division of General Surgery, Second Affiliated Hospital of Nanjing Medical University, ²Division of General Surgery, Hangzhou First People's Hospital Affiliated to Nanjing Medical University

A rat model, namely radiation plus transplantation, was introduced to promote the homing of intravenously injected mesenchymal stem cells to an irradiated vascular segment. The model found its application in the assessment of mesenchymal stem cell therapy for radiation vasculitis.

JoVE Core

Morphological and Functional Evaluation of Ribbon Synapses at Specific Frequency Regions of the Mouse Cochlea

Shu-Kui Yu^*1, Zheng-De Du^*1, Qing-Ling Song¹, Teng-Fei Qu¹, Yue Qi¹, Wei Xiong¹, Lu He¹, Wei Wei², Shu-Sheng Gong¹, Ke Liu¹

¹Department of Otolaryngology-Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, ²Department of Otology, Shengjing Hospital of China Medical University

This manuscript describes an experimental protocol for evaluating the morphological characteristics and functional status of ribbon synapses in normal mice. The present model is also suitable for noise-induced and age-related cochlear synaptopathy-restricted models. The correlative results of previous mouse studies are also discussed.

Medicine

Traditional Trail Making Test Modified into Brand-new Assessment Tools: Digital and Walking Trail Making Test

Wei Wei^*1, Hóngyi Zhào^*1,2, Yu Liu², Yonghua Huang¹

¹Department of Neurology, The Seventh Medical Center of PLA Army General Hospital, ²Department of Neurology, NO 984 Hospital of PLA

Here, we present a protocol to show how to perform two types of cognitive assessment tools derived from the paper-pencil version of the Trail Making Test.