Left Atrial Stenosis Induced Pulmonary Venous Arterialization and Group 2 Pulmonary Hypertension in RatPing Yu Xiong *1,2, Shunsuke Baba *3,4, Naritomo Nishioka 3,5, Yoshitaka Fujimoto 3, Stephen L. Archer 1, Susumu Minamisawa 1,4
1Department of Medicine, Queen's University, 2Department of Biomedical and Molecular Sciences, Queen's University, 3Department of Cell Physiology, The Jikei University School of Medicine, 4Department of Pediatrics, The Jikei University School of Medicine, 5Department of Cardiovascular Surgery, The Jikei University School of Medicine
Left atrial stenosis (LAS) is a novel surgical technique used for studying group 2 pulmonary hypertension (PH) and mechanisms underlying pulmonary venous arterialization. Here, we present a protocol to constrict the left atrium using a titanium clip to cause pulmonary venous arterialization and moderate PH in a rat.
