Hebei University of Economics and Business

1 ARTICLES PUBLISHED IN JoVE

Neuroscience

Caenorhabditis elegans as a Model System for Discovering Bioactive Compounds Against Polyglutamine-Mediated Neurotoxicity

Qiangqiang Wang^*1, Ju Zhang^*2, Yiyi Jiang^1,3, Yue Xiao¹, Xiaomin Li³, Xinliang Mao³, Zebo Huang¹

¹Institute for Food Nutrition and Human Health, School of Food Science and Engineering, South China University of Technology, ²School of Bioscience and Bioengineering, Hebei University of Economics and Business, ³Perfect Life & Health Institute

Here, we present a protocol to assess the neuroprotective activities of test compounds in Caenorhabditis elegans, including polyglutamine aggregation, neuronal death, and chemoavoidance behavior, as well as an exemplary integration of multiple phenotypes.