A Preclinical Controlled Cortical Impact Model for Traumatic Hemorrhage Contusion and NeuroinflammationHung-Fu Lee *1, Chih Hung Chen *2, Che-Feng Chang 2
1Department of Neurosurgery, Cheng Hsin General Hospital, 2Graduate Institute of Physiology, College of Medicine, National Taiwan University
Intraparenchymal hemorrhage and neuroinflammation accompanied by cerebral contusion can trigger severe secondary brain injury. This protocol details a mouse controlled cortical impact (CCI) model allowing researchers to study hemorrhage contusion and post-traumatic immune responses and explore potential therapeutics.
