Atlanta VA Medical Center

2 ARTICLES PUBLISHED IN JoVE

Bioengineering

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography

Rachael S. Allen^1,2, Katie Bales^1,3, Andrew Feola^1,2, Machelle T Pardue^1,2,3

¹Center of Excellence for Visual and Neurocognitive Rehabilitation, Atlanta Veterans Affairs Medical Center, ²Department of Biomedical Engineering, Georgia Institute of Technology, ³Department of Ophthalmology, Emory University

Here, we describe the use of spectral-domain optical coherence tomography (SD-OCT) to visualize retinal and ocular structures in vivo in models of retinal degeneration, glaucoma, diabetic retinopathy, and myopia.

Behavior

Behavioral Assessment of Visual Function via Optomotor Response and Cognitive Function via Y-Maze in Diabetic Rats

Kaavya Gudapati^*1,2, Anayesha Singh^*1,3, Danielle Clarkson-Townsend^1,4, Stephen Q. Phillips¹, Amber Douglass¹, Andrew J. Feola^1,2, Rachael S. Allen^1,2

¹Center for Visual and Neurocognitive Rehabilitation, Atlanta VA Medical Center, ²Department of Biomedical Engineering, Georgia Institute of Technology, ³Department of Neuroscience, Emory University, ⁴Gangarosa Department of Environmental Health, Emory University

Neural degeneration in both eyes and brain as a result of diabetes can be observed through behavioral tests carried out on rodents. The Y-maze, a measure of spatial cognition, and the optomotor response, a measure of visual function, both provide insight into potential diagnoses and treatments.