University Medical Center Groningen

6 ARTICLES PUBLISHED IN JoVE

Medicine

The C-seal: A Biofragmentable Drain Protecting the Stapled Colorectal Anastomosis from Leakage

Annelien N. Morks¹, Klaas Havenga¹, Henk O. ten Cate Hoedemaker¹, Rutger J. Ploeg¹

¹Department of Surgery, Division of Abdominal Surgery, University Medical Center Groningen

The C-seal is a biofragmentable drain protecting the stapled colorectal anastomosis. In this video, details of the manufacturing, deployment and use are shown.

Medicine

Multispectral Real-time Fluorescence Imaging for Intraoperative Detection of the Sentinel Lymph Node in Gynecologic Oncology

Lucia M.A. Crane¹, George Themelis², K. Tim Buddingh¹, Niels J. Harlaar¹, Rick G. Pleijhuis¹, Athanasios Sarantopoulos², Ate G.J. van der Zee³, Vasilis Ntziachristos², Gooitzen M. van Dam¹

¹Department of Surgery, Division of Surgical Oncology, University Medical Center Groningen, ²Helmholtz Zentrum, Technical University Munich, ³Department of Obstetrics and Gynaecology, University Medical Center Groningen

Fluorescence imaging is a promising innovative modality for image-guided surgery in surgical oncology. In this video we describe the technical procedure for detection of the sentinel lymph node using fluorescence imaging as showcased in gynecologic oncologicy. A multispectral fluorescence camera system, together with the fluorescent agent indocyanine green, is applied.

Medicine

Tissue-simulating Phantoms for Assessing Potential Near-infrared Fluorescence Imaging Applications in Breast Cancer Surgery

Rick Pleijhuis¹, Arwin Timmermans¹, Johannes De Jong¹, Esther De Boer¹, Vasilis Ntziachristos², Gooitzen Van Dam¹

¹Department of Surgery, University Medical Center Groningen, ²Helmholtz Zentrum Munich, Technical University of Munich

Near-infrared fluorescence (NIRF) imaging may improve therapeutic outcome of breast cancer surgery by enabling intraoperative tumor localization and evaluation of surgical margin status. Using tissue-simulating breast phantoms containing fluorescent tumor-simulating inclusions, potential clinical applications of NIRF imaging in breast cancer patients can be assessed for standardization and training purposes.

Behavior

An Automated Method to Determine the Performance of Drosophila in Response to Temperature Changes in Space and Time

Andrea Soto-Padilla^1,2, Rick Ruijsink³, Mark Span⁴, Hedderik van Rijn^*4, Jean-Christophe Billeter^*1

¹Groningen Institute for Evolutionary Life Sciences, University of Groningen, ²Department of Cell Biology, University of Groningen, University Medical Center Groningen, ³Ruijsink Dynamic Engineering, ⁴Department of Psychology, University of Groningen

Here we present a protocol to automatically determine the locomotor performance of Drosophila at changing temperatures using a programmable temperature-controlled arena that produces fast and accurate temperature changes in time and space.

JoVE Core

Observational Study Protocol for Repeated Clinical Examination and Critical Care Ultrasonography Within the Simple Intensive Care Studies

Renske Wiersema¹, Jose N. Castela Forte¹, Thomas Kaufmann², Robbert J. de Haas³, Geert Koster¹, Yoran M. Hummel⁴, Jacqueline Koeze¹, Casper F. M. Franssen⁵, Madelon E. Vos¹, Bart Hiemstra¹, Frederik Keus¹, Iwan C.C. van der Horst¹

¹Department of Critical Care, University of Groningen, University Medical Center Groningen, ²Department of Anesthesiology, University of Groningen, University Medical Center Groningen, ³Department of Radiology, University of Groningen, University Medical Center Groningen, ⁴Department of Cardiology, University of Groningen, University Medical Center Groningen, ⁵Division of Nephrology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen

Structured protocols are necessary to provide answers on research questions in critically ill patients. The Simple Intensive Care Studies (SICS) provides an infrastructure for repeated measurements in critically ill patients including clinical examination, biochemical analysis and ultrasonography. SICS projects have specific focus but the structure is flexible to other investigations.

Education

Determining and Controlling External Power Output During Regular Handrim Wheelchair Propulsion

Rick de Klerk¹, Riemer J. K. Vegter¹, Marika T. Leving¹, Sonja de Groot^1,2, DirkJan H. E. J. Veeger^3,4, Lucas H. V. van der Woude^1,5

¹Center for Human Movement Sciences, University Medical Center Groningen, ²Amsterdam Rehabilitation Research Center Reade, Amsterdam, ³Research Institute MOVE, Faculty of Behavioral and Human Movement Sciences, VU University, ⁴3M, Delft University of Technology, Delft, ⁵Center for Rehabilitation, University Medical Center Groningen

Accurate and standardized assessment of external power output is crucial in the evaluation of physiological, biomechanical, and perceived stress, strain, and capacity in manual wheelchair propulsion. The current article presents various methods to determine and control power output during wheelchair propulsion studies in the laboratory and beyond.