A Murine Model of Cervical Spinal Cord Injury to Study Post-lesional Respiratory NeuroplasticityEmilie Keomani 1, Thérèse B. Deramaudt 1, Michel Petitjean 1,2, Marcel Bonay 1,2, Frédéric Lofaso 1,3, Stéphane Vinit 1
1UFR des sciences de la santé - Simone Veil, Université de Versailles Saint-Quentin-en-Yvelines, 2Service de Physiologie - Explorations fonctionnelles, Hôpital Ambroise Paré, 3Services de Physiologie, Explorations Fonctionnelles, Réanimation Médicale et Centre d'Investigation Clinique et d'Innovation Technologique (Unité Inserm 805), Université de Versailles Saint-Quentin-en-Yvelines
Respiratory failure is the leading cause of death following a cervical spinal cord injury. Having a reproducible, quantifiable, and reliable pre-clinical animal model of respiratory failure induced by a partial cervical injury will help to understand the subsequent respiratory and non-respiratory neuroplasticity and allow testing putative repair strategies.
